K. Zhao, J. K. Vasquez, H. E. Blackwell. "Potent pan-group quorum sensing inhibitors in Staphylococcus aureus revealed by N-terminal tailoring of peptidomimetics." Chem. Commun., 2023, 59 (5), 587-590.(DOI 10.1039/D2CC05733F)

C. G. Gahan, R. C. Van Lehn, H. E. Blackwell, D. M. Lynn. "Interactions of Bacterial Quorum Sensing Signals with Model Lipid Membranes: Influence of Membrane Composition on Membrane Remodeling." Langmuir 2023, 39 (1), 295-307. (DOI 10.1021/acs.langmuir.2c02506)

T. J. Polaske, K. H. J. West, K. Zhao, D. L. Widner, J. T. York, H. E. Blackwell. "Chemical and biomolecular insights into the Staphylococcus aureus agr quorum sensing system: Current progress and ongoing challenges." Isr. J. Chem., 2023. (DOI

K. H. J. West, S. V. Ma, D. A. Pensinger, T. Tucholski, T. N. Tiambeng, E. E. Eisenbraun, A. Yehuda, Z. Hayouka, Y. Ge, J. D. Sauer, H. E. Blackwell. "Characterization of an Autoinducing Peptide Signal Reveals Highly Efficacious Synthetic Inhibitors and Activators of Quorum Sensing and Biofilm Formation in Listeria monocytogenes." Biochem., 2023. (DOI

Q. Zhang, V. Linke, K. A. Overmyer, L. L. Traeger, K. Kasahara, I. J. Miller, D. E. Manson, T. J. Polaske, R. L. Kerby, J. H. Kemis, E. A. Trujillo, T. R. Reddy, J. D. Russell, K. L. Schueler, D. S. Stapleton, M. E. Rabaglia, M. Seldin, D. M. Gatti, G. R. Keele, D. T. Pham, J. P. Gerdt, E. I. Vivas, A. J. Lusis, M. P. Keller, G. A. Churchill, H. E. Blackwell, K. W. Broman, A. D. Attie, J. J. Coon, F. E. Rey. "Genetic mapping of microbial and host traits reveals production of immunomodulatory lipids by Akkermansia muciniphila in the murine gut." Nat. Microbiol., 2023, 8 (3), 424-440. (DOI


T. J. Polaske, C. G. Gahan, K. E. Nyffeler, D. M. Lynn, and H. E. Blackwell. “Identification of Small Molecules that Strongly Inhibit Bacterial Quorum Sensing Using a High-Throughput Lipid Vesicle Lysis Assay.” Cell Chem. Biol., 2022, 29, 1-10. (DOI 10.1016/j.chembiol.2021.12.005)

M. J. Styles, M. E. Boursier, M. A. McEwan, E. E. Santa, M. E. Mattmann, B. L. Slinger, and H. E. Blackwell. "Autoinducer-fluorophore conjugates enable FRET in LuxR proteins in vitro and in cells." Nat. Chem. Biol., 2022. (DOI

K. E. Nyffeler, E. E. Santa, H. E. Blackwell. "Small Molecules with Either Receptor-Selective or Pan-Receptor Activity in the Three LuxR-Type Receptors that Regulate Quorum Sensing in Pseudomonas aeruginosa." ACS Chemical Biology 2022, 17 (11), 2979-2985. (DOI 10.1021/acschembio.2c00675)

H. Agarwal, L. D. J. Quinn, S. C. Walter, T. J. Polaske, D. H. Chang, S. P. Palecek, H. E. Blackwell and D. M. Lynn. "Slippery Antifouling Polymer Coatings Fabricated Entirely from Biodegradable and Biocompatible Components." ACS Applied Materials & Interfaces, 2022, 14, 17940-17949. (DOI 10.1021/acsami.1c25218)

K. H. J. West, C. G. Gahan, P. R. Kierski, D. F. Calderon, K. Zhao, C. J. Czuprynski, J. F. McAnulty, D. M. Lynn, H. E. Blackwell. "Sustained Release of a Synthetic Autoinducing Peptide Mimetic Blocks Bacterial Communication and Virulence In Vivo." Angew. Chem. Int. Ed. 2022, 61, 134. (DOI e202201798)


K. H. J. West, W. Shen, E. L. Eisenbraun, T. Yang, J. K. Vasquez, A. R. Horswill, and H. E. Blackwell. "Non-Native Peptides Capable of Pan-Activating the agr Quorum Sensing System across Multiple Specificty Groups of Staphylococcus epidermidis." ACS Chem. Biol. 2021, 16 (6), 1070-1078. (DOI 10.1021/acschembio.1c00240)

H. Agarwal, T. J. Polaske, G. Sánchez-Velázquez, H. E. Blackwell, and D. M. Lynn. “Slippery Nanoemulsion-Infused Porous Surfaces (SNIPS): Anti-Fouling Coatings that Can Host and Sustain the Release of Water-Soluble Agents.” Chemical Communications, 2021, 57. In press.

H. Agarwal, K. E. Nyffeler, H. E. Blackwell, and D. M. Lynn. “Fabrication of Slippery Liquid-Infused Coatings in Flexible Narrow-Bore Tubing.” ACS Applied Materials and Interfaces, 2021, 13, In press.

C. G. Gahan, R. C. Van Lehn, H. E. Blackwell, and D. M. Lynn, “Interactions of Bacterial Quorum Sensing Signals with Model Lipid Membranes: Influence of Acyl Tail Structure on Multi-Scale Response.” Langmuir, 2021, 37(41), 12049-12058. (DOI 10.1021/acs.langmuir.1c01825)

H. Agarwal, K. E. Nyffeler, U. Manna, H. E. Blackwell, and D. M. Lynn. "Liquid Crystal-Infused Porous Polymer Surfaces: A “Slippery” Soft Material Platform for the Naked-Eye Detection and Discrimination of Amphiphilic Species." ACS Appl. Mater. Interfaces, 2021, 13 (28), 33652-33663. (DOI 10.1021/acsami.1c08170)

C. G. Gahan, S. J. Patel, L. M. Chen, D. E. Manson, Z. J. Ehmer, H. E. Blackwell, R. C. Van Lehn, and D. M. Lynn. "Bacterial Quorum Sensing Signals Promote Large-Scale Remodeling of Lipid Membranes." Langmuir 2021, 37(30), 9120-9136. (DOI 10.1021/acs.langmuir.1c01204)


D. E. Manson, M. C. O'Reilly, K. E. Nyffeler, and H. E. Blackwell. "Design, synthesis, and biochemical characterization of non-native antagonists of the Pseudomonas aeruginosa quorum sensing receptor LasR with nanomolar IC50 values." ACS Infect. Dis. 2020, 6 (4), 649-661. (DOI 10.1021/acsinfecdis.9b00518)

C. G. Gahan, S. J. Patel, M. E. Boursier, K. E. Nyffeler, J. Jennings, N. L. Abbott, H. E. Blackwell, R. C. Van Lehn, and D. M. Lynn. "Bacterial Quorum Sensing Signals Self-Assemble in Aqueous Media to Form Micelles and Vesicles: An Integrated Experimental and Molecular Dynamics Study." J. Phys. Chem. B 2020, 124 (18), 3616-3628. (DOI 10.1021/acs.jpcb.0c00496)

B. J. Ortiz, M. E. Boursier, K. L. Barrett, D. E. Manson, D. Amador-Noguez, N. L. Abbott, H. E. Blackwell, and D. M. Lynn. "Liquid Crystal Emulsions That Intercept and Report on Bacterial Quorum Sension." ACS Appl. Mater. Interfaces 202012(26), 29056-29065. (DOI 10.1021/acsami.0c05792)

M. J. Styles, S. A. Early, T. Tucholski, K. H. J. West, Y. Ge, and H. E. Blackwell. "Chemical control of quorum sensing in E. coli: identification of small molecule modulators of SdiA and mechanistic characterization of a covalent inhibitor." ACS Infect. Dis. 2020, 6(12), 3092-3103. (DOI 10.1021/acsinfecdis.0c00654)


J. K. Vasquez and H. E. Blackwell. "Simplified Autoinducing Peptide Mimetics with Single-Nanomolar Activity Against the Staphylococcus aureus AgrC Quorum Sensing Receptor." ACS Infect. Dis. 2019, 5 (4), 484-492. (DOI 10.1021/acsinfecdis.9b00002)

M. E. Boursier, J. B. Combs, and H. E. Blackwell. "N-Acyl l-Homocysteine Thiolactones Are Potent and Stable Synthetic Modulators of the RhlR Quorum Sensing Receptor in Pseudomonas aeruginosa." ACS Chem. Biol. 2019, 14, 186-191. (DOI 10.1021/acschembio.8b01079)

D. Shin, C. Gorgulla, M. E. Boursier, N. Rexrode, E. C. Brown, H. ArthanariH. E. Blackwell, and R. Nagarajan. “N-Acyl homoserine lactone analog modulators of the Pseudomonas aeruginosa RhlI quorum sensing signal synthase.” ACS Chem. Biol. 2019, 14(10), 2305-2314. (DOI 10.1021/acschembio.9b00671)

B. L. Slinger, J. J. Deay, J. R. Chandler, and H. E. Blackwell. "Potent modulation of the CepR quorum sensing receptor and virulence in a Burkholderia cepacia complex member using non-native lactone ligands." Sci. Rep. 2019, 9. (DOI 10.1038/s41598-019-49693-x)

J. K. Vasquez, K. H. J. West, T. Yang, T. J. Polaske, G. Cornilescu, M. Tonelli and H. E. Blackwell. "Conformational Switch to a β-turn in a Staphylococcal Quorum Sensing Signal Peptide Causes a Dramatic Increase in Potency." J. Am. Chem. Soc. 2019, 142 (2), 750 -761. (DOI 10.1021/jacs.9b05513)


C. L. Wysoczynski-Horita,  M. E. Boursier, R. Hill, K. Hansen, H. E. Blackwell, and M. E. A. Churchill. "Mechanism of agonism and antagonism of the Pseudomonas aeruginosa quorum sensing regulator QscR with non‐native ligands." Mol. Microbiol. 2018, 108(3), 240-257. (DOI 10.1111/mmi.13930)

M. C. O'Reilly, S-H Dong, F. M. Rossi, K. M. Karlen, R. S. Kumar, S. K. Nair, and H. E. Blackwell. "Structural and biochemical studies of non-native agonists of the LasR quorum-sensing receptor reveal an L3 Loop 'Out' conformation for LasR." Cell Chem. Biol. 2018, 25, 1-12. (DOI 10.1016/j.chembiol.2018.06.007)

M. E. Boursier, D. E. Manson, J. B. Combs, and H. E. Blackwell. "A comparative study of non-native N-acyl L-homoserine lactone analogs in two Pseudomonas aeruginosa quorum sensing receptors that share a common native ligand yet inversely regulate virulence." Bioorg. Med. Chem. 2018, 26, 5336-5342. (DOI 10.1016/j.bmc.2018.05.018)

M. E. Boursier, J. D. Moore, K. M. Heitman, S. P. Shepardson-Fungairino, J. B. Combs, L. C. Koenig, D. Shin, E. C. Brown, R. Nagarajan, and H. E. Blackwell. “Structure-function analyses of the N-butanoyl L-homoserine lactone quorum-sensing signal define features critical to activity in RhlR.” ACS Chem. Biol. 2018, 13, 2655-2662. (DOI: 10.1021/acschembio.8b00577)

J. A. Mooney, E. M. Pridgen, R. Manasherob, G. Suh, H. E. Blackwell, A. E. Barron, P. L. Bollyky, S. B. Goodman, and D. F. Amanatullah. “Implant-Associated Bacterial Biofilm and Quorum Sensing in Periprosthetic Joint Infections.” J. Orthop. Res. 2018, 36, 2331-2339. (DOI: 10.1002/jor.24019).

S. P. Brown, H. E. Blackwell, and B. K. Hammer. “The state of the union is strong: A review of ASM’s 6th conference on Cell-Cell Communication in Bacteria.” J. Bact. 2018, 200(14), e00291-18. (DOI: 10.1128/JB.00291-18).

A. G. Palmer, A. C. Senechal, T. C. Haire, N. P. Mehta, S. D. Valiquette, H. E. Blackwell. "Selection of appropriate autoinducer analogs for the modulation of quorum sensing at the host-bacteria interface." ACS Chem Biol. 2018, 13, 3115-3122. (DOI 10.1021/acschembio.8b00676).

M. J. Styles and H. E. Blackwell. "Non-native autoinducer analogs capable of modulating the SdiA quorum sensing receptor in Salmonella enterica serovar Typhimurium." Beilstein J. Org. Chem. 2018, 14, 2651–2664. (DOI 10.3762/bjoc.14.243)


J. K. Vasquez, Y. Tal-Gan, G. Cornilescu, K. A. Tyler, and H. E. Blackwell. "Simplified AIP-II Peptidomimetics are Potent Inhibitors of Staphylococcus aureus AgrC Quorum Sensing Receptors." ChemBioChem. 2017, 18, 413–423. (DOI 10.1002/cbic.201600516)

M. J. Kratochvil, T. Yang, H. E. Blackwell and D. M. Lynn. "Non-Woven Polymer Nanofiber Coatings that Inhibit Quorum Sensing in Staphylococcus aureus: Toward New Non-Bactericidal Approaches to Infection Control." ACS Infectious Diseases. 2017, 3, 271–280. (DOI 10.1021/acsinfecdis.6b00173)

J. P. Gerdt, D. M. Wittenwyler, J. B. Combs, M.E. Boursier, J. W. Brummond, H. Xu, and H.E. Blackwell. "Chemical Interrogation of LuxR-type Quorum Sensing Receptors Reveals New Insights into Receptor Selectivity and the Potential for Interspecies Bacterial Signaling." ACS Chem. Biol. 2017, 12, 2457-2464. (DOI 10.1021/acschembio.7b00458)

A. C. Schneider, D. Fritz, J. K. Vasquez, S. B. L. Vollrath, H. E. Blackwell, and S. Brase. "Microwave-Facilitated SPOT-Synthesis of Antibacterial Dipeptoids" ACS Comb. Sci. 2017, 19, 715-737. (DOI 10.1021/acscombsci.7b00096)


Y. Tal-Gan, M. Ivancic, G. Cornilescu, and H. E. Blackwell. "Characterization of Structural Elements in Native Autoinducing Peptides and Non-Native Analogues that Permit the Differential Modulation of AgrC-type Quorum Sensing Receptors in Staphylococcus aureus." Org. Biomol. Chem. 2016, 14, 113-121. (DOI 10.1039/C5OB01735A)

M. C. O'Reilly and H. E. Blackwell. "Structure-Based Design and Biological Evaluation of Triphenyl Scaffold Based Hybrid Compounds as Hydrolytically Stable Modulators of a LuxR-Type Quorum Sensing Receptor." ACS Infect. Dis. 2016, 2, 32–38. (DOI 10.1021/acsinfecdis.5b00112)

U. Manna, N. Raman, M. A. Welsh, Y. M. Zayas-Gonzalez, H. E. Blackwell, S. P. Palecek, and D. M. Lynn. “Slippery Liquid-Infused Porous Surfaces that Prevent Microbial Surface Fouling and Kill Non-Adherent Pathogens in Surrounding Media: A Controlled Release Approach.” Adv. Funct. Mat. 2016, 26, 3599-3611. (DOI 10.1002/adfm.201505522)

M. A. Welsh and H. E. Blackwell. "Chemical Genetics Reveals Environment-Specific Roles for Quorum Sensing Circuits in Pseudomonas aeruginosa." Cell Chem. Biol. 2016, 23, 361–369. (DOI 10.1016/j.chembiol.2016.01.006)

M. A. Welsh and H. E. Blackwell. "Chemical Probes of Quorum Sensing: From Compound Development to Biological Discovery." FEMS Microbiol. Rev. 2016, 40, 774-794. (DOI 10.1093/femsre/fuw009)

T. Yang, Y. Tal-Gan, A. E. Paharik, A. R. Horswill, and H. E. Blackwell. "Structure-Function Analyses of a Staphylococcus epidermidis Autoinducing Peptide Reveals Motifs Critical for AgrC-type Receptor Modulation" ACS Chem. Biol. 2016, 11, 1982-1991. (DOI 10.1021/acschembio.6b00120)

Y. Tal-Gan, M. Ivancic, G. Cornilescu, T. Yang, and H. E. Blackwell. "Highly Stable, Amide-Bridged Autoinducing Peptide Analogues that Strongly Inhibit the AgrC Quorum Sensing Receptor in Staphylococcus aureus." Angew. Chem. Int. Ed. 2016, 55, 8913-8917. (DOI 10.1002/anie.201602974)

M. J. Kratochvil, M. A. Welsh, U. Manna, B. J. Ortiz, H. E. Blackwell, and D. M. Lynn. "Slippery Liquid-Infused Porous Surfaces that Prevent Bacterial Surface Fouling and Inhibit Virulence Phenotypes in Surrounding Planktonic Cells." ACS Infect. Dis. 2016, 2, 509-517. (DOI 10.1021/acsinfecdis.6b00065)

N. M. Patel, J. D. Moore, H. E. Blackwell, and D. Amador-Noguez. "Identification of unanticipated and novel N-acyl homoserine lactones (AHLs) using a sensitive non-targeted LC-MS/MS method." PLOS One. 2016, 11, e0163469. (DOI 10.1371/journal.pone.0163469)

A. G. Palmer, A. Mukherjee, D. M. Stacy, S. Lazar, J.-M. Ané, and H. E. Blackwell. "Interkingdom Responses to Bacterial Quorum Sensing Signals Regulate Frequency and Rate of Nodulation in Legume–Rhizobia Symbiosis." ChemBioChem. 2016, 17, 2199–2205. (DOI 10.1002/cbic.201600373)


J. P. Gerdt, C. E. McInnis, T. L. Schell, and H. E. Blackwell. "Unraveling the contributions of hydrogen-bonding interactions to the activity of native and non-native ligands in the quorum-sensing receptor LasR." Org. Biomol. Chem. 2015, 13, 1453-1462. (DOI 10.1039/C4OB02252A)

M. A. Welsh, N. R. Eibergen, J. D. Moore, and H. E. Blackwell. "Small molecule disruption of quorum sensing cross-regulation in Pseudomonas aeruginosa causes major and unexpected alterations to virulence phenotypes." J. Am. Chem. Soc. 2015, 137, 1510-1519. (DOI 10.1021/ja5110798)

M. J. Kratochvil, Y. Tal-Gan, T. Yang, H. E. Blackwell, and D. M. Lynn. "Nanoporous Superhydrophobic Coatings that Promote the Extended Release of Water-Labile Quorum Sensing Inhibitors and Enable Long-Term Modulation of Quorum Sensing in Staphylococcus aureus." ACS Biomater. Sci. Eng. 2015, 1, 1039-1049. (DOI 10.1021/acsbiomaterials.5b00313)

N. R. Eibergen, J. D. Moore, M. E. Mattmann, and H. E. Blackwell. "Potent and Selective Modulation of the RhlR Quorum Sensing Receptor using Non-Native Ligands - An Emerging Target for Virulence Control in Pseudomonas aeruginosa." Chembiochem. 2015, 6, 2348–2356. (DOI 10.1002/cbic.201500357)

J. D. Moore, F. M. Rossi, M. A. Welsh, K. E. Nyffeler, and H. E. Blackwell. "A comparative analysis of synthetic quorum sensing modulators in Pseudomonas aeruginosa: New insights into mechanism, active efflux susceptibility, phenotypic response, and next-generation ligand design." J. Am. Chem. Soc. 2015, 137, 14626–14639. (DOI 10.1021/jacs.5b06728)


A. H. Broderick, D. M. Stacy, Y. Tal-Gan, M. J. Kratochvil, H. E. Blackwell, and D. M. Lynn. "Surface Coatings that Promote Rapid Release of Peptide-Based AgrC Inhibitors for Attenuation of Quorum Sensing in Staphylococcus aureus." Adv. Healthcare Mater. 2014, 3, 97-105. (DOI 10.1002/adhm.201300119)

C. E. McInnis and H. E. Blackwell. "Non-Native N-Aroyl L-Homoserine Lactones Are Potent Modulators of the Quorum Sensing Receptor RpaR in Rhodopseudomonas palustris." ChemBioChem. 2014, 15, 87-93. (DOI 10.1002/cbic.201300570)

J. D. Moore, J. P. Gerdt, N. R. Eibergen, and H. E. Blackwell. "Active Efflux Influences the Potency of Quorum Sensing Inhibitors in Pseudomonas aeruginosa." ChemBioChem. 2014, 15, 435-442. (DOI 10.1002/cbic.201300701)

Y. Tal-Gan, D. M. Stacy, and H. E. Blackwell. "N-Methyl and Peptoid Scans of an Autoinducing Peptide Reveal New Structural Features Required for Inhibition and Activation of AgrC Quorum Sensing Receptors in Staphylococcus aureus." Chem. Commun. 2014, 50, 3000-3003. (DOI 10.1039/C4CC00117F)

A. G. Palmer, A. Senechal, A. Mukherjee, J.-M. Ané, and H. E. Blackwell. "Plant Responses to Bacterial N-Acyl L-Homoserine Lactones are Dependent on Enzymatic Degradation to L-Homoserine." ACS Chem. Biol. 20149, 1834-1845. (DOI 10.1021/cb500191a)

J. P. Gerdt and H. E. Blackwell. "Competition studies confirm two major barriers that can preclude the spread of resistance to quorum-sensing inhibitors in bacteria." ACS Chem. Biol. 20149, 2291-2299. (DOI 10.1021/cb5004288)

J. P. Gerdt, C. E. McInnis, T. L. Schell, F. M. Rossi, and H. E. Blackwell. "Mutational Analysis of the Quorum-Sensing Receptor LasR Reveals Interactions that Govern Activation and Inhibition by Nonlactone Ligands."Chem. Biol. 201421, 1361-1369. (DOI 10.1016/j.chembiol.2014.08.008)


A. H. Broderick, A. S. Breitbach, R. Frei, H. E. Blackwell, and D. M. Lynn. “Surface-Mediated Release of a Small-Molecule Modulator of Bacterial Biofilm Formation: A Non-Bactericidal Approach to Inhibiting Biofilm Formation in Pseudomonas aeruginosa.” Adv. Healthcare Mater. 2013, 2, 993-1000. (DOI 10.1002/adhm.201200334)

J. A. Crapster, I. A. Guzei, and H. E. Blackwell. "A Peptoid Ribbon Secondary Structure." Angew. Chem. Int. Ed.. 2013, 52, 5079-5084. (DOI 10.1002/anie.201208630)

D. M. Stacy, S. T. Le Quement, C. L. Hansen, J. W. Clausen, T. Tolker-Nielsen, J. W. Brummond, M. Givskov, T. E. Nielsen, and H. E. Blackwell. “Synthesis and Biological Evaluation of Triazole-Containing N-Acyl Homoserine Lactones as Quorum Sensing Modulators.” Org. Biomol. Chem. 2013, 11, 938-954. (DOI 10.1039/C2OB27155A)

Y. Tal-Gan, M. Ivancic, G. Cornilescu, C. Cornilescu, and H. E. Blackwell. "Structural Characterization of Native Autoinducing Peptides and Abiotic Analogs Reveals Key Features Essential for Activation and Inhibition of an AgrC Quorum Sensing Receptor in Staphylococcus aureus." J. Am. Chem. Soc. 2013, 135, 18436–18444. (DOI 10.1021/ja407533e)

Y. Tal-Gan, D. M. Stacy, M. K. Foegen, D. W. Koenig, and H. E. Blackwell. “Highly Potent Inhibitors of Quorum Sensing in Staphylococcus aureus Revealed Through a Systematic Synthetic Study of the Group-III Autoinducing Peptide.” J. Am. Chem. Soc. 2013, 135, 7869-7882. (DOI 10.1021/ja3112115)


A. G. Palmer, E. Streng, and H. E. Blackwell. “Attenuation of virulence in pathogenic bacteria using synthetic quorum-sensing modulators under native conditions on plant hosts.” ACS Chem. Biol. 2012, 6, 1348-1356. (DOI 10.1021/cb200298g)

R. Frei, A. S. Breitbach, and H. E. Blackwell. "Expedient Construction of Small-Molecule Macroarrays via Sequential Palladium- and Copper-Mediated Reactions and Their ex situ Biological Testing" Chem. Sci. 2012, 3, 1555-1561. (DOI 10.1039/C2SC01089E

R. Frei, A. S. Breitbach, and H. E. Blackwell. "2-Aminobenzimidazole Derivatives Strongly Inhibit and Disperse Pseudomonas aeruginosa Biofilms" Angew. Chem. Int. Ed. 2012, 51, 5226-5229. (DOI 10.1002/anie.201109258)

D. M. Stacy, M. A. Welsh, P. N. Rather, and H. E. Blackwell. "Attenuation of quorum sensing in the pathogen Acinetobacter baumannii using non-native N-acyl homoserine lactones." ACS Chem. Biol. 2012, 7, 1719-1728. (DOI 10.1021/cb300351x)

T. Praneenararat, A. G. Palmer, and H. E. Blackwell. “Chemical Methods to Interrogate Bacterial Quorum Sensing Pathways.” Org. Biomol. Chem. 2012, 10, 8189-8199. (DOI 10.1039/C2OB26353J)


A. G. Palmer, E. Streng, K. A. Jewell, and H. E. Blackwell. "Quorum Sensing in Bacterial Species that Use Degenerate Autoinducers Can Be Tuned by Using Structurally Identical Non-native Ligands" ChemBioChem. 2011, 12, 138-147. (DOI 10.1002/cbic.201000551)

M. E. Mattmann, N. J. Heth. P. M. Shipway, and H. E. Blackwell. “Potent and Selective Synthetic Modulators of a Quorum Sensing Repressor in Pseudomonas aeruginosa Identified from Second-Generation Libraries of N-Acylated L-Homoserine Lactones” ChemBioChem, 2011, 12, 942-949. (DOI 10.1002/cbic.201000708)

J. R. Stringer, M. D. Bowman, B. Weisblum, and H. E. Blackwell. “An Improved Small-Molecule Macroarray Platform for the Rapid Synthesis and Discovery of Antibacterial Chalcones” ACS Comb. Sci., 2011, 13, 175-180. (DOI 10.1021/co100053p)

C. E. McInnis and H. E. Blackwell. “Thiolactone Modulators of Quorum Sensing Revealed Through Library Design and Screening” Bioorg. Med. Chem. 2011, 19, 4820-4828. (DOI 10.1016/j.bmc.2011.06.071)

C. E. McInnis and H. E. Blackwell. “Design, Synthesis, and Biological Evaluation of Abiotic, Non-Lactone Modulators of LuxR-type Quorum Sensing.” Bioorg. Med. Chem. 2011, 19, 4812-4819. (DOI 10.1016/j.bmc.2011.06.072)

T. Praneenararat, T. M. Beary, A. S. Breitbach, and H. E. Blackwell. “Synthesis and Application of an N-Acylated L-Homoserine Lactone Derivatized Affinity Matrix for the Isolation of Quorum Sensing Signal Receptors” Bioorg. Med. Chem. Lett., 2011, 21, 5054-5057. (DOI 10.1016/j.bmcl.2011.04.062)

J. R. Stringer, J. A. Crapster, I. A. Guzei, and H. E. Blackwell. “Extraordinarily Robust Polyproline Type I Peptoid Helices Generated via the Incorporation of α-Chiral Aromatic N-1-Naphthylethyl Side Chains.” J. Am. Chem. Soc. 2011, 133, 15559-15567. (DOI 10.1021/ja204755p)

A. Lindemann, G. Pessi, A. L. Schaefer, M. E. Mattmann, Q. H. Christensen, A. Kessler, H. H. Hennecke, H. E. Blackwell, E. P. Greenberg, and C. S. Harwood. "Quorum sensing in the soybean symbiont Bradyrhizobium japonicum: identification of isovaleryl-homoserine lactone, an unusual branched-chain signal." Proc. Natl. Acad. Sci. U.S.A. 2011, 108, 16765-16770. (DOI 10.1073/pnas.1114125108)

A. S. Breitbach, A. H. Broderick, C. M. Jewell, S. Gunasekaran, Q. Li, D. M. Lynn, and H. E. Blackwell. "Surface-mediated release of a synthetic small-molecule modulator of bacterial quorum sensing: Gradual release enhances activity" Chem. Commun. 2011, 47, 370-372. (DOI 10.1039/C0CC02316G)

J. A. Crapster, J. R. Stringer, I. A. Guzei, and H. E. Blackwell. “Design and Conformational Analysis of Peptoids Containing N-Hydroxy Amides Reveals a Unique Sheet-Like Secondary Structure.” Biopolymers. 2011, 96, 604-616. (DOI 10.1002/bip.21599)


J. R. Stringer, J. A. Crapster, I. A. Guzei, and H. E. Blackwell. "Construction of Peptoids with All Trans-Amide Backbones and Peptoid Reverse Turns via the Tactical Incorporation of N-Aryl Side Chains Capable of Hydrogen Bonding" J. Org. Chem. 2010, 75, 6068-6078. (DOI 10.1021/jo101075a)

B. R. Borlee, G. D. Geske, H. E. Blackwell, J. Handelsman. "Identification of Synthetic Inducers and Inhibitors of the Quorum-Sensing Regulator LasR in Pseudomonas aeruginosa by High-Throughput Screening" Appl. Envir. Microbiol. 2010, 76, 8255-8258. (DOI 10.1128/AEM.00499-10)

R. Frei and H. E. Blackwell. "Small Molecule Macroarray Construction via Palladium-Mediated Carbon-Carbon Bond Forming Reactions: Highly Efficient Synthesis and Screening of Stilbene Arrays" Chem-Eur J. 2010, 16, 2692-2695. (DOI 10.1002/chem.200903445)

M. E. Mattmann and H. E. Blackwell. "Small Molecules That Modulate Quorum Sensing and Control Virulence in Pseudomonas aeruginosa" J. Org. Chem. 2010, 75, 6737-6746. (DOI 10.1021/jo101237e)


J. Campbell and H. E. Blackwell. "Efficient Construction of Diketopiperazine Macroarrays Through a Cyclative-Cleavage Strategy and Their Evaluation as Luminescence Inhibitors in the Bacterial Symbiont Vibrio fischeri" J. Comb. Chem. 2009, 11, 1094-1099. (DOI 10.1021/cc900115x)

B. C. Gorske, J. R. Stringer, B. L. Bastian, S. A. Fowler, and H. E. Blackwell. “New Strategies for the Design of Folded Peptoids Revealed by a Survey of Noncovalent Interactions in Model Systems” J. Am. Chem. Soc. 2009, 131, 16555-16567. (DOI 10.1021/ja907184g)

T. Praneenararat, G. D. Geske and H. E. Blackwell. “Efficient Synthesis and Evaluation of Quorum-Sensing Modulators Using Small Molecule Macroarrays” Org. Lett. 2009, 11, 4600-4603. (DOI 10.1021/ol901871y)

J. C. O’Neill, G. D. Geske, Q. Lin, and H. E. Blackwell. “New and Unexpected Insights into the Modulation of LuxR-type Quorum Sensing by Cyclic Dipeptides” ACS Chem. Bio. 2009, 12, 1051-1059. (DOI 10.1021/cb900165y)

M. E. Buck, A. S. Breitbach, S. K. Belgrade, H. E. Blackwell, and D. M. Lynn. “Chemical Modification of Reactive Multilayered Films Fabricated from Poly(2-Alkenyl Azlactone)s: Design of Surfaces that Prevent or Promote Mammalian Cell Adhesion and Bacterial Biofilm Growth” Biomacromolecules 2009, 10, 1564-1574. (DOI 10.1021/bm9001552)

S. A. Fowler, R. Luechapanichkul, and H. E. Blackwell. “Synthesis and Characterization of Nitroaromatic Peptoids: Fine Tuning Peptoid Secondary Structure Through Monomer Position and Functionality” J. Org. Chem. 2009, 74, 1440-1449. (DOI 10.1021/jo8023363)

S. A. Fowler and H. E. Blackwell. “Structure-function relationships in peptoids: Recent advances toward deciphering the structural requirements for biological function.” Org. Biomol. Chem. 2009, 7, 1508-1524. (DOI 10.1039/b817980h)


B. R. Borlee, G. D. Geske, C. J. Robinson, H. E. Blackwell, and J. Handelsman. “Quorum-Sensing Signals in the Microbial Community of the Cabbage White Butterfly Larval Midgut” ISME Journal, 2008, 2, 1101-1111. (DOI 10.1038/ismej.2008.70)

S. A. Fowler, D. M. Stacy, and H. E. Blackwell. “Design and Synthesis of Macrocyclic Peptomers as Mimics of a Quorum Sensing Signal from Staphylococcus aureus" Org. Lett. 2008, 10, 2329-2332. (DOI 10.1021/ol800908h)

M. E. Mattmann, G. D. Geske, G. A. Worzalla, J. R. Chandler, K. J. Sappington, E. P. Greenberg, and H. E. Blackwell. “Synthetic Ligands that Activate and Inhibit a Quorum-Sensing Regulator in Pseudomonas aeruginosaBioorg. Med. Chem. Lett. 2008, 18, 3072-3075. (DOI 10.1016/j.bmcl.2007.11.095)

G. D. Geske, J. C. O’Neill, D. M. Miller, M. E. Mattmann, Q. Lin, R. J. Wezeman, and H. E. Blackwell. “Comparative Analysis of N-Acyl Homoserine Lactones Reveals Unique Structural Features that Dictate Their Ability to Activate or Inhibit Quorum Sensing” ChemBioChem 2008, 9, 389-400. (DOI 10.1002/cbic.200700551)

A.G. Palmer and H. E. Blackwell. “Deciphering a Proto-Language for Bacteria-Host Communication” Nat. Chem. Bio., 2008, 4, 452-454. (DOI 10.1038/nchembio0808-452)

G. D. Geske, J. C. O’Neill and H. E. Blackwell. “Expanding Dialogues: From Natural Autoinducers to Non-Natural Analogues that Modulate Quorum Sensing in Gram-Negative Bacteria” Chem. Soc. Rev., 2008, 37, 1432-1447. (DOI 10.1039/B703021P)

G. D. Geske, M. E. Mattmann, and H. E. Blackwell. “Evaluation of a Focused Library of N-aryl L-Homoserine Lactones Reveals a New Set of Potent Quorum Sensing Modulators” Bioorg. Med. Chem. Lett., 2008, 18, 5978-5981. (DOI 10.1016/j.bmcl.2008.07.089)


G. D. Geske, J. C. O’Neill, D. M. Miller, M. E. Mattmann, and H. E. Blackwell. “Modulation of Bacterial Quorum Sensing: Systematic Evaluation of N-Acylated Homoserine Lactones in Multiple Species and New Insights into Their Mechanism of Action” J. Am. Chem. Soc. 2007, 129, 13613-13625. (DOI 10.1021/ja074135h)

I. A. Guzei, L. C. Spencer, Q. Lin, and H. E. Blackwell. “N-{(Aminocarbonyl)[(S)-4-itrobenzyl]methyl}-N- {[(R)-cyclohexyl](cyclohexylaminocarbonyl)methyl}propanamide methanol solvate” Acta Cryst. 2007, E63, 1892-1894. (DOI 10.1107/S1600536807012299)

M. D. Bowman, J. C. O’Neill, J. R. Stringer, and H. E. Blackwell. “Rapid Identification of Antibacterial Agents Effective Against Staphylococcus aureus Using Small Molecule Macroarrays” Chem. Biol. 2007, 14, 351-357. (DOI 10.1016/j.chembiol.2007.03.006)

Y. Y. Chan, H. S. Bian, T. M. C. Tan, M. E. Mattmann, G. D. Geske, J. Igarashi, T. Hatano, H. Suga, H. E. Blackwell, and K. L. Chau. “ Control of Quorum Sensing by a Burkholderia pseudomallei Multidrug Efflux Pump.” J. Bacteriol. 2007, 189, 4320-4324. (DOI 10.1128/JB.00003-07)

G. D. Geske, J. C. O’Neill, and H. E. Blackwell. “N-Phenylacetanoyl-L-Homoserine Lactones Can Strongly Antagonize or Super-Agonize Quorum Sensing in Vibrio fischeriACS Chem. Biol. 2007, 2, 315-320. (DOI 10.1021/cb700036x)

B. C. Gorske, B. L. Bastian, G. D. Geske, and H. E. Blackwell. “Local and Tunable n→π* Interactions Regulate Amide Isomerism in the Peptoid Backbone.” J. Am. Chem. Soc. 2007, 129, 8928-8929. (DOI 10.1021/ja071310l)

J. C. O’Neill and H. E. Blackwell. “Solid-Phase and Microwave-Assisted Syntheses of 2,5-Diketopiperazines: Small Molecules with Great Potential” Comb. Chem. High T. Scr. 2007, 10, 857-876. (DOI 10.2174/138620707783220365)


Q. Lin and H. E. Blackwell. “Rapid Synthesis of Diketopiperazine Macroarrays via Ugi Four-Component Reactions” Chem. Commun. 2006, 2884-2886. (DOI 10.1039/b604329a)

B. C. Gorske and H. E. Blackwell. “Tuning Peptoid Secondary Structure with Pentafluoroaromatic Functionality: A New Design Paradigm for the Construction of Discretely Folded Peptoid Structures” J. Am. Chem. Soc. 2006, 128, 14378-14387. (DOI 10.1021/ja065248o)

I. A. Guzei, B. C. Gorske, and H. E. Blackwell. “N-(1-Pentafluorophenyl-ethyl)-acetamide” Acta Cryst. 2006, C62, o286-o288. (DOI 10.1107/S0108270106012121)

M. D. Bowman, M. M. Jacobson, B. G. Pujanauski, and H. E. Blackwell. “Efficient Synthesis of Small Molecule Macroarrays: Optimization of the Macroarray Synthesis Platform and Examination of Microwave and Conventional Heating Methods” Tetrahedron (Symposium-in-Print on Microwaves in Organic Chemistry) 2006, 62, 4715-4727. (DOI 10.1016/j.tet.2006.02.083)

M. D. Bowman, M. M. Jacobson, and H. E. Blackwell. “Discovery of Fluorescent Cyanopyridine and Deazalumazine Dyes using Small Molecule Macroarrays” Org. Lett. 2006, 8, 1645-1648. (DOI 10.1021/ol0602708)

H. E. Blackwell. “Hitting the SPOT: Small molecule macroarrays advance combinatorial synthesis” Curr. Opin. Chem. Biol. 2006, 10, 203-212. (DOI 10.1016/j.cbpa.2006.04.026)

B. C. Gorske and H. E. Blackwell. “Interception of Quorum Sensing in Staphylococcus aureus: A New Niche for Peptidomimetics” Org. Biomol. Chem. 2006, 4, 1441-1445. (DOI 10.1039/b517681f)

J. J. Hollenbeck, E. N. Wixson, G. D. Geske, M. W. Dodge, T. A. Tseng, A. D. Clauss, and H. E. Blackwell. “A Model for Transitioning Students from the Undergraduate Teaching Lab to the Research Laboratory: The Evolution of an Intermediate Organic Synthesis Laboratory Course” J. Chem. Educ. 2006, 83, 1835-1843. (DOI 10.1021/ed083p1835)


Q. Lin, J. C. O’Neill, and H. E. Blackwell. “Small Molecule Macroarray Construction via Ugi Four-Component Reactions” Org. Lett. 2005, 7, 4455-4458. (DOI 10.1021/ol051684o)

G. D. Geske, R. J. Wezeman, A. P. Seigel, and H. E. Blackwell. “Small Molecule Inhibitors of Bacterial Quorum Sensing and Biofilm Formation” J. Am. Chem. Soc. 2005, 127, 12762-12763. (DOI 10.1021/ja0530321)

B. C. Gorske, S. A. Jewell, E. J. Guerard, and H. E. Blackwell. “ Expedient Synthesis and Design Strategies for New Peptoid Construction” Org. Lett. 2005, 7, 1521-1524. (DOI 10.1021/ol0502984)

H. E. Blackwell. “Bacterial Crowd Control with Iron” Chem. Biol. 2005, 12, 721-723. (DOI 10.1016/j.chembiol.2005.07.001)


M. D. Bowman, R. C. Jeske, and H. E. Blackwell. “Microwave-Accelerated SPOT-Synthesis on Cellulose Supports” Org. Lett. 2004, 6, 2019-2022. (DOI 10.1021/ol049313f)


H. E. Blackwell and Y. Zhao. “Chemical Genetic Approaches to Plant Biology” Plant Physiol. 2003, 133, 448-455. (DOI 10.1104/pp.103.031138)

H. E. Blackwell. “Out of the Oil Bath and Into the Oven – Microwave-assisted Combinatorial Chemistry Heats Up” Org. Biomol. Chem. 2003, 1, 1251-1255. (DOI 10.1039/b301432k)