All Publications by Date

2013

  • J.A. Crapster and H.E. Blackwell. "A Peptoid Ribbon Secondary Structure" Angew. Chemie. 2012, 52, 5079-5084. (DOI 10.1002/anie.201208630)

  • Y. Tal-Gan, D.M. Stacy, M.K. Foegen, D.W. Koenig, and H.E. Blackwell. “Highly Potent Inhibitors of Quorum Sensing in Staphylococcus aureus Revealed Through a Systematic Synthetic Study of the Group-III Autoinducing Peptide.” J. Am. Chem. Soc. 2013, in press. (DOI 10.1021/ja3112115)

  • A. H. Broderick, D. M. Stacy, Y. Tal-Gan, M. J. Kratochvil, H. E. Blackwell, and D. M. Lynn, "Surface Coatings that Promote Rapid Release of Peptide-Based AgrC Inhibitors for Attenuation of Quorum Sensing in Staphylococcus aureus." Adv. Healthcare Mater. 2013, in press.

  • A. H. Broderick, A. S. Breitbach, R. Frei, H. E. Blackwell, and D. M. Lynn. “Surface-Mediated Release of a Small-Molecule Modulator of Bacterial Biofilm Formation: A Non-Bactericidal Approach to Inhibiting Biofilm Formation in Pseudomonas aeruginosa.” Adv. Healthcare Mater. 2013, in press. (DOI 10.1002/adhm.201200334)

  • D. M. Stacy, S. T. Le Quement, C. L. Hansen, J. W. Clausen, T. Tolker-Nielsen, J. W. Brummond, M. Givskov, T. E. Nielsen, and H. E. Blackwell. “Synthesis and Biological Evaluation of Triazole-Containing N-Acyl Homoserine Lactones as Quorum Sensing Modulators.” Org. Biomol. Chem. 2013, 11, 938-954. (DOI 10.1039/C2OB27155A)

2012

  • A. G. Palmer, E. Streng, and H. E. Blackwell. “Attenuation of virulence in pathogenic bacteria using synthetic quorum-sensing modulators under native conditions on plant hosts.” ACS Chem. Biol. 2012, 6, 1348-1356. (DOI 10.1021/cb200298g)

  • R. Frei, A. S. Breitbach, and H. E. Blackwell. "Expedient Construction of Small-Molecule Macroarrays via Sequential Palladium- and Copper-Mediated Reactions and Their ex situ Biological Testing" Chem. Sci. 2012, 3, 1555-1561. (DOI 10.1039/C2SC01089E) 

  • R. Frei, A. S. Breitbach, and H. E. Blackwell. "2-Aminobenzimidazole Derivatives Strongly Inhibit and Disperse Pseudomonas aeruginosa Biofilms" Angew. Chem. Int. Ed. Engl. 2012, 51, 5226-5229. (DOI 10.1002/anie.201109258)

  • D. M. Stacy, M. A. Welsh, P. N. Rather, and H. E. Blackwell. "Attenuation of quorum sensing in the pathogen Acinetobacter baumannii using non-native N-acyl homoserine lactones." ACS Chem. Biol. 2012, 7, 1719-1728. (DOI 10.1021/cb300351x)

  • T. Praneenararat, A. G. Palmer, and H. E. Blackwell. “Chemical Methods to Interrogate Bacterial Quorum Sensing Pathways.” Org. Biomol. Chem. 2012, 10, 8189-8199. (DOI 10.1039/C2OB26353J)

2011

  • A. G. Palmer, E. Streng, K. A. Jewell, and H. E. Blackwell. "Quorum Sensing in Bacterial Species that Use Degenerate Autoinducers Can Be Tuned by Using Structurally Identical Non-native Ligands" ChemBioChem. 2011, 12, 138-147. (DOI 10.1002/cbic.201000551)

  • A. S. Breitbach, A. H. Broderick, C. M. Jewell, S. Gunasekaran, Q. Li, D. M. Lynn, and H. E. Blackwell. "Surface-mediated release of a synthetic small-molecule modulator of bacterial quorum sensing: Gradual release enhances activity" Chem. Commun. 2011, 47, 370-372 (DOI 10.1039/C0CC02316G)

  • J. R. Stringer, M. D. Bowman, B. Weisblum, and H. E. Blackwell. “An Improved Small-Molecule Macroarray Platform for the Rapid Synthesis and Discovery of Antibacterial Chalcones” ACS Comb. Sci., 2011, 13, 175-180. (DOI 10.1021/co100053p)

  • M. E. Mattmann, N. J. Heth. P. M. Shipway, and H. E. Blackwell. “Potent and Selective Synthetic Modulators of a Quorum Sensing Repressor in Pseudomonas aeruginosa Identified from Second-Generation Libraries of N-Acylated L-Homoserine Lactones” ChemBioChem, 2011, 12, 942-949. (DOI 10.1002/cbic.201000708)

  • J. R. Stringer, J. A. Crapster, I. A. Guzei, and H. E. Blackwell. “Extraordinarily Robust Polyproline Type I Peptoid Helices Generated via the Incorporation of α-Chiral Aromatic N-1-Naphthylethyl Side Chains.” J. Am. Chem. Soc. 2011, 133, 15559-15567. (DOI 10.1021/ja204755p)

  • T. Praneenararat, T. M. Beary, A. S. Breitbach, and H. E. Blackwell. “Synthesis and Application of an N-Acylated L-Homoserine Lactone Derivatized Affinity Matrix for the Isolation of Quorum Sensing Signal Receptors” Bioorg. Med. Chem. Lett., 2011, 21, 5054-5057. (DOI 10.1016/j.bmcl.2011.04.062)

  • C. E. McInnis and H. E. Blackwell. “Thiolactone Modulators of Quorum Sensing Revealed Through Library Design and Screening” Bioorg. Med. Chem. 2011, 19, 4820-4828. (DOI 10.1016/j.bmc.2011.06.072)

  • C. E. McInnis and H. E. Blackwell. “Design, Synthesis, and Biological Evaluation of Abiotic, Non-Lactone Modulators of LuxR-type Quorum Sensing.” Bioorg. Med. Chem. 2011, 19, 4812-4819. (DOI 10.1016/j.bmc.2011.06.072)

  • A. Lindemann, G. Pessi, A. L. Schaefer, M. E Mattmann, Q. H Christensen, A. Kessler, H. H. Hennecke, H. E. Blackwell, E. P. Greenberg, and C. S. Harwood. "Quorum sensing in the soybean symbiont Bradyrhizobium japonicum: identification of isovaleryl-homoserine lactone, an unusual branched-chain signal." Proc. Natl. Acad. Sci. U.S.A. 2011, 108, 16765-16770. (DOI 10.1073/pnas.1114125108)

  • J. A. Crapster, J. R. Stringer, I. A. Guzei, and H. E. Blackwell. “Design and Conformational Analysis of Peptoids Containing N-Hydroxy Amides Reveals a Unique Sheet-Like Secondary Structure.” Biopolymers. 2011, 96, 604-616. (DOI 10.1002/bip.21599)

2010

  • J. R. Stringer, J. A. Crapster, I. A. Guzei, and H. E. Blackwell. "Construction of Peptoids with All Trans-Amide Backbones and Peptoid Reverse Turns via the Tactical Incorporation of N-Aryl Side Chains Capable of Hydrogen Bonding" J. Org. Chem. 2010, 75, 6068-6078. (DOI 10.1021/jo101075a)

  • B. R. Borlee, G. D. Geske, H. E. Blackwell, J. Handelsman. "Identification of Synthetic Inducers and Inhibitors of the Quorum-Sensing Regulator LasR in Pseudomonas aeruginosa by High-Throughput Screening" Appl. Envir. Microbiol. 2010, 76, 8255-8258. (DOI 10.1128/AEM.00499-10)

  • R. Frei and H. E. Blackwell. "Small Molecule Macroarray Construction via Palladium-Mediated Carbon-Carbon Bond Forming Reactions: Highly Efficient Synthesis and Screening of Stilbene Arrays" Chem-Eur J. 2010, 16, 2692-2695. (DOI 10.1002/chem.200903445)

  • M. E. Mattmann and H. E. Blackwell. "Small Molecules That Modulate Quorum Sensing and Control Virulence in Pseudomonas aeruginosa" J. Org. Chem. 2010, 75, 6737-6746. (DOI 10.1021/jo101237e)

2009

  • J. Campbell and H. E. Blackwell. "Efficient Construction of Diketopiperazine Macroarrays Through a Cyclative-Cleavage Strategy and Their Evaluation as Luminescence Inhibitors in the Bacterial Symbiont Vibrio fischeri" J. Comb. Chem. 2009, 11, 1094-1099. (DOI 10.1021/cc900115x)

  • B. C. Gorske, J. R. Stringer, B. L. Bastian, S. A. Fowler, and H. E. Blackwell. “New Strategies for the Design of Folded Peptoids Revealed by a Survey of Noncovalent Interactions in Model Systems” J. Am. Chem. Soc. 2009, 131, 16555-16567. (DOI 10.1021/ja907184g)

  • T. Praneenararat, G. D. Geske and H. E. Blackwell. “Efficient Synthesis and Evaluation of Quorum-Sensing Modulators Using Small Molecule Macroarrays” Org. Lett. 2009, 11, 4600-4603. (DOI 10.1021/ol901871y)

  • J. C. O’Neill, G. D. Geske, Q. Lin, and H. E. Blackwell. “New and Unexpected Insights into the Modulation of LuxR-type Quorum Sensing by Cyclic Dipeptides” ACS Chem. Bio. 2009, 12, 1051-1059. (DOI 10.1021/cb900165y)

  • M. E. Buck, A. S. Breitbach, S. K. Belgrade, H. E. Blackwell, and D. M. Lynn. “Chemical Modification of Reactive Multilayered Films Fabricated from Poly(2-Alkenyl Azlactone)s: Design of Surfaces that Prevent or Promote Mammalian Cell Adhesion and Bacterial Biofilm Growth” Biomacromolecules 2009, 10, 1564-1574. (DOI 10.1021/bm9001552)

  • S. A. Fowler, R. Luechapanichkul, and H. E. Blackwell. “Synthesis and Characterization of Nitroaromatic Peptoids: Fine Tuning Peptoid Secondary Structure Through Monomer Position and Functionality” J. Org. Chem. 2009, 74, 1440-1449. (DOI 10.1021/jo8023363)

  • S. A. Fowler and H. E. Blackwell. “Structure-function relationships in peptoids: Recent advances toward deciphering the structural requirements for biological function.” Org. Biomol. Chem. 2009, 7, 1508-1524. (DOI 10.1039/b817980h)

2008

  • G. D. Geske, M. E. Mattmann, and H. E. Blackwell. “Evaluation of a Focused Library of N-aryl L-Homoserine Lactones Reveals a New Set of Potent Quorum Sensing Modulators” Bioorg. Med. Chem. Lett., 2008, 18, 5978-5981. (DOI 10.1016/j.bmcl.2008.07.089)

  • B. R. Borlee, G. D. Geske, C. J. Robinson, H. E. Blackwell, and J. Handelsman. “Quorum-Sensing Signals in the Microbial Community of the Cabbage White Butterfly Larval Midgut” ISME Journal, 2008, 2, 1101-1111. (DOI 10.1038/ismej.2008.70)

  • S. A. Fowler, D. M. Stacy, and H. E. Blackwell. “Design and Synthesis of Macrocyclic Peptomers as Mimics of a Quorum Sensing Signal from Staphylococcus aureus" Org. Lett. 2008, 10, 2329-2332. (DOI 10.1021/ol800908h)

  • M. E. Mattmann, G. D. Geske, G. A. Worzalla, J. R. Chandler, K. J. Sappington, E. P. Greenberg, and H. E. Blackwell. “Synthetic Ligands that Activate and Inhibit a Quorum-Sensing Regulator in Pseudomonas aeruginosa” Bioorg. Med. Chem. Lett. 2008, 18, 3072-3075. (DOI 10.1016/j.bmcl.2007.11.095)

  • Grant D. Geske, Jennifer C. O’Neill, David M. Miller, Margrith E. Mattmann, Qi Lin, Rachel J. Wezeman, and Helen E. Blackwell. “Comparative Analysis of N-Acyl Homoserine Lactones Reveals Unique Structural Features that Dictate Their Ability to Activate or Inhibit Quorum Sensing” ChemBioChem 2008, 9, 389-400. (DOI 10.1002/cbic.200700551)

  • A.G. Palmer and H. E. Blackwell. “Deciphering a Proto-Language for Bacteria-Host Communication” Nat. Chem. Bio., 2008, 4, 452-454. (DOI 10.1038/nchembio0808-452)

  • G. D. Geske, J. C. O’Neill and H. E. Blackwell. “Expanding Dialogues: From Natural Autoinducers to Non-Natural Analogues that Modulate Quorum Sensing in Gram-Negative Bacteria” Chem. Soc. Rev., 2008, 37, 1432-1447. (DOI 10.1039/B703021P)

2007

  • Grant D. Geske, Jennifer C. O’Neill, David M. Miller, Margrith E. Mattmann, and Helen E. Blackwell. “Modulation of Bacterial Quorum Sensing: Systematic Evaluation of N-Acylated Homoserine Lactones in Multiple Species and New Insights into Their Mechanism of Action” J. Am. Chem. Soc. 2007, 129, 13613-13625. (DOI 10.1021/ja074135h)

  • Ilia A. Guzei, Lara C. Spencer, Qi Lin, and Helen E. Blackwell. “N-{(Aminocarbonyl)[(S)-4-itrobenzyl]methyl}-N- {[(R)-cyclohexyl](cyclohexylaminocarbonyl)methyl}propanamide methanol solvate” Acta Cryst. 2007, E63, 1892-1894. (DOI 10.1107/S1600536807012299)

  • Matthew D. Bowman, Jennifer C. O’Neill, Joseph R. Stringer, and Helen E. Blackwell. “Rapid Identification of Antibacterial Agents Effective Against Staphylococcus aureus Using Small Molecule Macroarrays” Chem. Biol. 2007, 14, 351-357. (DOI 10.1016/j.chembiol.2007.03.006)

  • Ying Ying Chan, Hau Sheng Bian, Theresa May Chin Tan, Margrith E. Mattmann, Grant D. Geske, Jin Igarashi, Tomomi Hatano, Hiroaki Suga, Helen E. Blackwell, and Kim Lee Chau. “ Control of Quorum Sensing by a Burkholderia pseudomallei Multidrug Efflux Pump.” J. Bacteriol. 2007, 189, 4320-4324. (DOI 10.1128/JB.00003-07)

  • Grant D. Geske, Jennifer C. O’Neill, and Helen E. Blackwell. “N-Phenylacetanoyl-L-Homoserine Lactones Can Strongly Antagonize or Super-Agonize Quorum Sensing in Vibrio fischeri” ACS Chem. Biol. 2007, 2, 315-320. (DOI 10.1021/cb700036x)

  • Benjamin C. Gorske, Brent L. Bastian, Grant D. Geske, and Helen E. Blackwell. “Local and Tunable n→π* Interactions Regulate Amide Isomerism in the Peptoid Backbone.” J. Am. Chem. Soc. 2007, 129, 8928-8929. (DOI 10.1021/ja071310l)

  • Jennifer C. O’Neill and Helen E. Blackwell. “Solid-Phase and Microwave-Assisted Syntheses of 2,5-Diketopiperazines: Small Molecules with Great Potential” Comb. Chem. High T. Scr. 2007, 10, 857-876. (DOI 10.2174/138620707783220365)

2006

  • Qi Lin and Helen E. Blackwell. “Rapid Synthesis of Diketopiperazine Macroarrays via Ugi Four-Component Reactions” Chem. Commun. 2006, 2884-2886. (DOI 10.1039/b604329a)

  • Benjamin C. Gorske and Helen E. Blackwell. “Tuning Peptoid Secondary Structure with Pentafluoroaromatic Functionality: A New Design Paradigm for the Construction of Discretely Folded Peptoid Structures” J. Am. Chem. Soc. 2006, 128, 14378-14387. (DOI 10.1021/ja065248o)

  • Ilia A. Guzei, Benjamin C. Gorske, and Helen E. Blackwell. “N-(1-Pentafluorophenyl-ethyl)-acetamide” Acta Cryst. 2006, C62, o286-o288. (DOI 10.1107/S0108270106012121)

  • Matthew D. Bowman, Megan M. Jacobson, Brian G. Pujanauski, and Helen E. Blackwell. “Efficient Synthesis of Small Molecule Macroarrays: Optimization of the Macroarray Synthesis Platform and Examination of Microwave and Conventional Heating Methods” Tetrahedron (Symposium-in-Print on Microwaves in Organic Chemistry) 2006, 62, 4715-4727. (DOI 10.1016/j.tet.2006.02.083)

  • Matthew D. Bowman, Megan M. Jacobson, and Helen E. Blackwell. “Discovery of Fluorescent Cyanopyridine and Deazalumazine Dyes using Small Molecule Macroarrays” Org. Lett. 2006, 8, 1645-1648. (DOI 10.1021/ol0602708)

  • Helen E. Blackwell. “Hitting the SPOT: Small molecule macroarrays advance combinatorial synthesis” Curr. Opin. Chem. Biol. 2006, 10, 203-212. (DOI 10.1016/j.cbpa.2006.04.026)

  • Benjamin C. Gorske and Helen E. Blackwell. “Interception of Quorum Sensing in Staphylococcus aureus: A New Niche for Peptidomimetics” Org. Biomol. Chem. 2006, 4, 1441-1445. (DOI 10.1039/b517681f)

  • Jessica J. Hollenbeck, Emily N. Wixson, Grant D. Geske, Matthew W. Dodge, T. Andrew Tseng, Allen D. Clauss and Helen E. Blackwell. “A Model for Transitioning Students from the Undergraduate Teaching Lab to the Research Laboratory: The Evolution of an Intermediate Organic Synthesis Laboratory Course” J. Chem. Educ. 2006, 83, 1835-1843. (DOI 10.1021/ed083p1835)

2005

  • Qi Lin, Jennifer C. O’Neill, and Helen E. Blackwell. “Small Molecule Macroarray Construction via Ugi Four-Component Reactions” Org. Lett. 2005, 7, 4455-4458. (DOI 10.1021/ol051684o)

  • Grant D. Geske, Rachel J. Wezeman, Adam P. Seigel, and Helen E. Blackwell. “Small Molecule Inhibitors of Bacterial Quorum Sensing and Biofilm Formation” J. Am. Chem. Soc. 2005, 127, 12762-12763. (DOI 10.1021/ja0530321)

  • Benjamin C. Gorske, Sarah A. Jewell, Emily J. Guerard, and Helen E. Blackwell. “ Expedient Synthesis and Design Strategies for New Peptoid Construction” Org. Lett. 2005, 7, 1521-1524. (DOI 10.1021/ol0502984)

  • Helen E. Blackwell. “Bacterial Crowd Control with Iron” Chem. Biol. 2005, 12, 721-723. (DOI 10.1016/j.chembiol.2005.07.001)

2004

  • Matthew D. Bowman, Ryan C. Jeske, and Helen E. Blackwell. “Microwave-Accelerated SPOT-Synthesis on Cellulose Supports” Org. Lett. 2004, 6, 2019-2022. (DOI 10.1021/ol049313f)

2003

  • Helen E. Blackwell and Yunde Zhao. “Chemical Genetic Approaches to Plant Biology” Plant Physiology 2003, 133, 448-455. (DOI 10.1104/pp.103.031138)

  • Helen E. Blackwell. “Out of the Oil Bath and Into the Oven – Microwave-assisted Combinatorial Chemistry Heats Up” Org. Biomol. Chem. 2003, 1, 1251-1255. (DOI 10.1039/b301432k)